Lupus Nephritis Class II: A Challenging Entity

Most of the literature focused on proliferative forms lupic Glomerulonephritis. Clinicians are increasingly confronted with cases nephropathy purely mesangial (class II). The aim our study is to describe mode presentation class II Lupus nephropathy, evaluate its evolutionary profile, and investigate possible risk factors for therapeutic misresponse, relapse or histological transformation. This a retrospective descriptive analytical conducted in nephrology depratement at Hassan university hospital Fez from January 2009 until September 2018. We included 20 patients. average age was 33.8 ± 7.25 years [22 - 50 years]. Nephropathy inaugurated half cases. mean time onset relation disease 36.7 45.4 months [1 144 months]. main reason consultation non-nephrotic proteinuria (65%). Renal failure revealed diagnosis three All patients had positive immunologic assessment. 90% received oral corticosteroid therapy immunosuppressive 3 Remission has been noted all After an follow-up period 39 23 [6 92 months], 45% relapsed. A second biopsy performed 80% showing histologic transformation four patients, requiring therapy. showed that occurrence significantly related presence known seniority. Proteinuria 12 also higher relapsed group. One patient died as result neurological complications. Another Evolved into chronic end stage renal put hemodialysis.